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Platelet-rich Plasma in Joints Pain: The Science of PRP Intra-articular Injection

Healthy Joints

If you are suffering from joint pain, your doctor may have recommended a Platelet-rich plasma (PRP) injection. PRP is a treatment that uses the patient’s blood to help heal injured tissue. In this article, we will discuss what PRP is, how it works, and the process of intra-articular PRP injection.

A healthy joint requires a balance of cartilage, fluid, and bone. The cartilage is a smooth, rubbery tissue that covers the ends of bones and allows them to move smoothly against each other. The balance is maintained by producing and repairing these tissues through fine-tuned molecular signalling that controls homeostasis, damage, restoration, and remodelling of the joint tissues. Some of the most common joint medical conditions, such as osteoarthritis (OA)balance, are due to balance disruption.

Painful joints

Joints can become painful when this balance is disrupted, and the tissues are damaged. Non-pharmacological modalities, dietary supplements, pharmacological therapies, and minimally invasive procedures involving injections of various substances are available to restore joint homeostasis, provide clinical improvement, and possibly have a disease-modifying effect in patients with osteoarthritis. More intrusive surgical techniques may prevent metal resurfacing when conventional therapies fail by restoring mechanical equilibrium and regenerating the articular surface, but the outcomes are still debatable. Even though some of these techniques have been found to have a good clinical outcome at midterm follow-up, rehabilitation is lengthy and long-term effects are sometimes uncertain, partial, and restricted.

PRP mechanism of action in joint healing

Multiple in vivo and in vitro studies showed supporting results to the effectiveness of the PRP in stimulating joint healing and restoration process. The PRP injection promotes the healing of chondral or osteochondral lesions and rheumatoid arthritis through some of the following possible mechanisms of action

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The process of intra-articular PRP injection

Dr. Salem Tomi uses a doppler to guide the PRP needle into the joint space. PRP is then injected into the joint space. The volume of the injected PRP varies according to the joints. For example, the PRP volume injected is usually between 0.25-0.50 mL for a small joint such as the wrist or ankle. For a larger joint such as the knee, hip, or shoulder, the PRP volume injected is usually between 4 to 6 mls

The PRP injection process takes less than 30 minutes from start to finish. Patients can usually return to their normal activities the same day or the next day. PRP injections are usually given once a week for three to six weeks.

PRP joint injections are most effective for patients who have early-stage joint damage. PRP may not be as effective if you have significant joint damage or arthritis. During your consultation, your doctor can determine if you are a good candidate for this treatment.
There is some evidence that PRP can help to regenerate cartilage. However, more research is needed in this area. Injections of PRP have the potential to help in cartilage regeneration by boosting the body’s natural capacity to speed up healing.
You should not take any anti-inflammatory medications for two weeks before your injection. This includes over-the-counter medications such as ibuprofen and aspirin. You should also avoid alcohol for 24 hours before your injection.
After the procedure, you may experience some pain and swelling at the injection site. This is normal and should resolve within a few days. You may also have some bruising. You will be given a list of activities to avoid for the first 24 hours after your injection. These include strenuous activity, prolonged standing or sitting, and hot showers or baths.
Most patients see improvement within four to six weeks after their initial injection. However, it may take up to three months to see full results.
The most common side effect is temporary pain and swelling at the injection site. Other potential side effects include infection, nerve damage, and joint stiffness. Talk to your doctor about the risks and benefits of this treatment before deciding if it is right for you. PRP is considered to be a safe treatment with few risks. The most common risk is temporary pain and swelling at the injection site. Other potential risks include infection, nerve damage, and joint stiffness. Talk to your doctor about the risks and benefits of this treatment before deciding if it is right for you.

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Platelet-rich Plasma in Joints Pain

PRP injection for shoulder bursitis

Bursitis is a condition that can cause pain and inflammation in the shoulder. The condition is often caused by overuse or repetitive motion and can be difficult to treat. However, one treatment option that is becoming increasingly popular is using PRP injections. PRP, or platelet-rich plasma, is a substance derived from the patient’s blood. The PRP is injected into the shoulder and helps promote healing by providing a source of growth factors. In addition, the PRP injection can help to reduce inflammation and pain. As a result, it is an effective treatment option for many patients with bursitis.

PRP injection for a knee injury

Platelet-rich plasma (PRP) is a concentration of platelets that is injected into an injured site to promote healing. PRP is derived from the patient’s own blood, so there is no risk of rejection or allergic reaction. PRP injections often treat injuries to tendons, ligaments, and muscles. Injections of PRP into the knee effectively treat chronic tendinitis, patellar tendinitis, and quadriceps tendon rupture. PRP has also been used to treat other joint injuries, including hip and shoulder injuries. The most common side effects of PRP injections are pain and swelling at the injection site. These side effects usually resolve within a few days.PRP injections are a safe and effective treatment for many types of knee injuries.

Other indications for PRP

Hair loss

The platelets are injected into the scalp, releasing growth factors that stimulate hair follicles and promote hair growth. PRP therapy effectively treats both male and female pattern baldness and is a relatively safe and low-risk procedure. Moreover, PRP injections can be combined with other hair loss treatments, such as hair transplants, to improve results further. As such, PRP therapy may be an ideal option for patients who are seeking to improve their hairline and restore their confidence.

Skin Rejuvenation

PRP skin rejuvenation is a new, minimally-invasive treatment that can help to improve the appearance of sun-damaged and aging skin. The treatment involves injecting a patient’s own platelet-rich plasma (PRP) into the skin. PRP is a concentration of platelets and growth factors derived from the patient’s blood. These growth factors have been shown to promote the formation of new collagen and elastin, resulting in smoother, firmer skin. In addition, PRP injections can help to improve the appearance of fine lines, wrinkles, and acne scars. The results of PRP skin rejuvenation are typically natural and long-lasting. For best results, multiple sessions may be necessary.

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